Therefore, this study aimed to assess the ability of live recombinant L. monocytogenes to stimulate CD8+ T cell-mediated anti-tumor immunity in animal models lacking the essential regulatory and effector molecules of necroptosis (RIPK3 and MLKL) and pyroptosis (caspase 1/11 and Gasdermin D (GSDMD)). The gene discussed is GSDMD; the disease is neoplasm.