SLC5A2 and hydrops fetalis: Finally, of outmost importance is the fact that loop diuretics activate RAAS and SNS, the two fundamental pathways in HF progression, and these side effects must be countered by the co-administration of RAAS inhibitors (angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/angiotensin receptor–neprilysin inhibitors (ARNI)/mineralocorticoid receptor antagonists (MRA)), β-blockers, and sodium–glucose transporter 2 (SGLT2) inhibitors (SGLT2i) [72].