However, genomic alterations were also detected in different cancer-relevant genes, including FAT atypical cadherin 1 (FAT1), LDL receptor-related protein 1B (LRP1B), cyclin-dependent kinase inhibitor 2A (CDKN2A), tet methylcytosine dioxygenase 2 (TET2), notch receptor 1 (NOTCH1,) and neuregulin 1 (NRG1). This evidence concerns the gene NOTCH1 and cancer.