To understand the role of miRNA-34a in RANKL-induced bone resorption and osteoclastogenesis in osteoporosis, it was revealed that targeting miR-34a by transforming growth factor beta-induced factor 2 (Tgif2) increased bone resorption, suggesting it to be a key osteoclast suppressor and skeletal processor [52]. This evidence concerns the gene TNFSF11 and osteoporosis.