The inhibition of miR-182 was also observed to downregulate RANKL-induced bone resorption and osteoclastogenesis in RA monocytes by targeting double-stranded RNA-dependent protein kinase (PKR) and mediating beta interferons(IFN-β) [64,92].The administration of miR-135b into exosomes derived from mesenchymal stem cells targeted PDCD4 mRNA to mitigate bone loss, hence ameliorating osteonecrosis of femoral head (ONFH) severity in a rat model [46]. Here, IFNB1 is linked to familial avascular necrosis of femoral head.