The most frequently mutated gene of the WNT/β-catenin pathway in colorectal cancers, APC was more often mutated in the non- CDX2-suppressed group (85% of the cases) compared with the CDX2-suppressed group (APC mutations in 40% of cases, Fisher’s exact test p < 0.0001, Figure 6). Here, APC is linked to colorectal cancer.