For example, inflammation during airway infections and the recurrence of infectious airway diseases are significantly decreased after spa inhalation treatment [12,13,14], as well as tumor necrosis factor alpha (TNFα) and calprotectin levels in nasal mucosa [15], or interleukin (IL)-1 and IL-6 levels in nasal washes chronic obstructive pulmonary disease [11,16]. Here, TNF is linked to chronic obstructive pulmonary disease.