TXNIP and carcinoma of the ampulla of vater: In the distal bile duct/ampullary carcinoma cohort, high cytoplasmic TxNIP and nuclear TrxR expression levels were significantly associated with age > 60 years (χ2 = 3.892, df = 1, p = 0.049 and χ2 = 5.091, df = 1, p = 0.024, respectively) (Table 2 and Table 3).