FGF23 and chronic kidney disease: We have previously reported that elevations of serum FGF23 can induce cardiac myocyte hypertrophy via FGFR4-mediated PLCγ/calcineurin/NFAT signaling, and that deleting or blocking FGFR4 abrogates the hypertrophic effects observed in mice on high-phosphate diet and in a rat model of CKD [26,34].