Notably, the MRL/lpr, poly (I:C) and mIFNα all showed upregulation of Stat1, a commonly reported SLE-associated signal transducer and transcription factor downstream of Type I IFN signaling, while the NZB/W and GvHD models did not (Figure 1C) [27]. Here, STAT1 is linked to systemic lupus erythematosus.