Notably, T cell-checkpoint-signaling DEGs in SLE human CD4+ T cells as well as B cell-receptor-signaling DEGs in SLE human B cells were positively associated with gene changes observed in the poly (I:C) and MRL/lpr models, but there was no association with gene changes in the mIFNα model (Figure 3B). This evidence concerns the gene CD4 and systemic lupus erythematosus.