For example, mutations in the presenilin genes PSEN1 and PSEN2 associated with early familial AD are also associated with dilated cardiomyopathy (CM) and HF [47], while the ApoE4 has also been associated with ischemic heart disease, myocardial infarction (MI), and AS [11,48]. This evidence concerns the gene APOE and myocardial infarction.