Moreover, the transcriptomic analysis of normal vs malignant prostate tissue highlighted the role of the non-coding small nucleolar RNA and the small Cajal body-specific RNA (SCARNA22) in the transition of PC from stage T2c to T3/T4. It also showed Neuronal Regeneration-Related Protein (NREP) transcript to be upregulated in the T3 and T4 invasive stages of PC, where cancer cells usually metastasize beyond the prostatic capsule [66]. The gene discussed is NREP; the disease is pachyonychia congenita.