Importantly, Solé et al. sequenced the entire circulating urinary transcriptome and discovered five mRNA biomarkers (FTH1, BRPF1, OSBP, PHC3, and UACA) that are able to differentiate amongst confounding diagnosis of BPH, low-stage PC, and high-stage PC [65]. This evidence concerns the gene OSBP and pachyonychia congenita.