Importantly, Solé et al. sequenced the entire circulating urinary transcriptome and discovered five mRNA biomarkers (FTH1, BRPF1, OSBP, PHC3, and UACA) that are able to differentiate amongst confounding diagnosis of BPH, low-stage PC, and high-stage PC [65]. The gene discussed is PHC3; the disease is pachyonychia congenita.