POLE and colorectal carcinoma: The TCGA CRC and GC cohorts were subtyped into chromosomal instability (CIN, CRC and GC), microsatellite instability (MSI, CRC and GC), genome-stable (GS, CRC and GC), POLE (CRC and GC) and Epstein-Barr (EBV, GC only) subtypes.