RANGAP1 and neurodegenerative disease: Here, we show that dysfunction of the RBP, hnRNP A1, modelled through its knockdown, which mimics a loss of homeostatic function in neurodegenerative diseases, results in alterations to the NCT machinery, including perturbations in nuclear envelope morphology, abnormalities in Nups and RanGAP1, a nuclear transport receptor, and changes in active NCT.