MAPT and Classical progressive supranuclear palsy: Progressive supranuclear palsy (PSP), first described by Steele, Richardson, and Olszewski in 1964, is believed to be caused by tauopathy, where gain of toxic function is caused by tau aggregates formed through aberrant post-translational modifications, such as excessive phosphorylation, and loss of function occurs due to a reduction in normal tau function [1].