TDP-43 pathology, which is initially defined by the accumulation of phosphorylated TDP-43 protein in the cytoplasm of vulnerable neurons, is broadly observed in the brains of patients diagnosed with ALS, FTD (frontotemporal dementia), ALS/FTD, AD, and many others [16,17,18,19,20,21]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.