We observed a significant decrease of PSD95 but not synaptophysin in LPS-exposed rats, which is consistent with the findings that PSD95 is reduced in a number of neurodevelopmental disorders such as Autism Spectrum Disorders (ASD) [33], and likewise, the findings that synaptic proteins are dysregulated in animal models involving neuroinflammation. Here, DLG4 is linked to neurodevelopmental disorder.