Genetic variations in the VDR gene (FokI, BsmI, ApaI, TaqI, Cdx−2, Tru9I) have been significantly linked to several types of cancer including prostate, breast, skin, bladder, ovarian, hepatocellular carcinoma, and colorectal cancer [12,21,36,41,42,43,44]. This evidence concerns the gene CDX2 and cancer.