One of them is IL-13, a cytokine that has been found in high levels in active LN patients [36], and is known to positively regulate the expression of ALG-2-interacting protein X (ALIX) [37], which is a multifunctional player involved in multivesicular body biogenesis, endocytic membrane trafficking, and apoptosis [38]. This evidence concerns the gene IL13 and lobular neoplasia.