Herbal preparations protect the liver from hepatic diseases by ameliorating gut dysbiosis, restoring gut barrier integrity, promoting gut-derived SCFA production, attenuating increased serum liver enzymes and lipids, improving liver pathology, inhibiting hepatic fatty acid accumulation, suppressing inflammation and insulin resistance, restoring antioxidant status, reducing oxidative stress, and altering BA metabolism. This evidence concerns the gene INS and liver disorder.