The expression of CCL17, interleukin (IL)-1β (IL1β), IL13, S100 calcium-binding protein A9 (S100A9), and transforming growth factor β1 (TGFβ1) was significantly elevated in AD patients, while the expression of filaggrin (FLG) and involucrin (IVL) was significantly reduced compared to healthy controls. This evidence concerns the gene IVL and Alzheimer disease.