We analyzed the chemokine signaling pathway of lymphoma and CH and identified 38 DEGs, including GNG4, CXCL14, CXCL9, GNG7, RASGRP2, CCR2, CCL11, ITK, GNG2, CCR6, CCL5, VAV2, PRKCD, CCL21, CCL17, CCL19, LYN, CCL22, GNB5, PRKCB, ADRBK2, CXCR3, CCR5, HCK, CSK, GNGT2, CXCR4, STAT1, CCR7, GRK6, ADCY7, CXCR5, PREX1, PIK3CD, RAC2, DOCK2, JAK3, and VAV1 (Supplementary S3). Here, CCL21 is linked to cyclic hematopoiesis.