KEGG analysis results showed that the top 20 upregulated signaling pathways included BCR signaling, TCR signaling, and chemokine signaling (Figure 2C), whereas the downregulated signaling pathways included TGFβ signaling pathways, pathways in cancer, and calcium signaling pathways (Figure 2D) (Supplementary S3). The gene discussed is TGFB1; the disease is cancer.