It is known that in the case of rheumatoid arthritis, interactions occur between a variety of cells (in particular, macrophages, T and B cells, synovial fibroblasts, as well as mast, dendritic and plasma cells) in the inflamed synovial membrane of joints, causing a release of proinflammatory mediators (TNF-α, IL-1β, and IL-6) [57]. The gene discussed is TNF; the disease is rheumatoid arthritis.