The comparative analysis of population frequencies of unfavorable alleles and genotypes of TCF7L2 (rs7903146) and PPARG (rs1801282) confirms their high genetic heterogeneity, reflecting the population structure peculiarities of the Kazakh people and indicating the need for association genomic studies of prediabetes and T2D in each ethnic population. The gene discussed is PPARG; the disease is prediabetes syndrome.