Population characteristics of allelic and genotypic distributions of the PPARG (Peroxisome proliferator-activated receptor gamma, rs1801282) and TCF7L2 (Transcription Factor 7 Like 2, rs7903146) gene polymorphisms, potentially associated with the development of prediabetes, were examined based on genotyping data from 1800 individuals of Kazakh ethnicity. Here, TCF7L2 is linked to prediabetes syndrome.