The high population frequency of carrying the minor G allele of the rs180128 polymorphism in the PPARG gene in the studied Kazakh sample, the conflicting results, and the significant ethnic differences observed, along with the high geographic diversity of its population frequencies, justified our choice of this polymorphism for investigating its potential role as a protective marker for the development of prediabetes in the Kazakh population. This evidence concerns the gene PPARG and prediabetes syndrome.