Population characteristics of allelic and genotypic distributions of the PPARG (Peroxisome proliferator-activated receptor gamma, rs1801282) and TCF7L2 (Transcription Factor 7 Like 2, rs7903146) gene polymorphisms, potentially associated with the development of prediabetes, were examined based on genotyping data from 1800 individuals of Kazakh ethnicity. The gene discussed is PPARG; the disease is prediabetes syndrome.