Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a key member of the tumor necrosis factor (TNF) superfamily, selectively induces apoptosis in cancer cells [7,8] by binding to death receptors 4 and 5 (DR4/5) [9], triggering intracellular signaling and leading to programmed cell death [10]. This evidence concerns the gene TNFRSF10A and cancer.