The oncogenic effect of TRIM59 can also be observed through the Wnt/β-catenin signaling pathway, where TRIM59 overexpression upregulated β-catenin and enhanced cell proliferation in neuroblastoma [188], but whether the effect is inherited from other signaling crosstalk or the direct interaction of TRIM59 with Wnt signaling molecules is still unknown. This evidence concerns the gene TRIM59 and neuroblastoma.