TRIM65 and cancer: Various studies have also suggested the involvement of TRIM proteins in both radio-resistant and chemo-resistant cancer cells [45], for example, TRIM29 and TRIM37, in suppressing the radiosensitivity of lung cancer and colorectal adenocarcinoma [46], and TRIM11, TRIM23, TRIM29 and TRIM65 in promoting the cisplatin-resistant tumorigenesis of various cancers [40,47,48,49].