More precisely, basal 17-OHP concentrations of <2 ng/mL (6nM) have been proposed for the exclusion of 21-OHD, with a more accurate measurement for 17-OHP concentrations after the ACTH stimulation test to be >10 ng/mL (30nM) for the diagnosis of 21-OHD [9,10,11]. Here, POMC is linked to classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.