The onset of BCC has been associated with the altered expression of several genes, including the gene for melanocortin 1 receptor (mc1r), oculocutaneous albinism type 2 gene (OCA2), p53, agouti signaling protein (ASIP), and tyrosinase (TYR) [29,67], but the most relevant is the inappropriate activation of the Hedgehog (HH) signaling pathway, which is also present in Gorlin Goltz syndrome or multiple basal cell nevus syndrome. This evidence concerns the gene MC1R and skin basal cell carcinoma.