Notably, the data presented in Figure 5, Figure 6 and Figure 7 suggest that the cancer cells at the early stage of tumor development orchestrated the angiogenic (IL-15, Il-18, M-CSF, VEGF, and FGFβ), proinflammatory (LIF, MIG, and MIP-2), and fibrogenic (PDGF-BB) cytokines to establish neovasculature to form blood vessels for tumor growth but decrease their effectiveness when the tumor starts to grow at day 35. This evidence concerns the gene VEGFA and neoplasm.