Here, we find that pancreatic cancer cells orchestrated host angiogenic, fibrogenic, and proinflammatory cytokine profiling as well as the endothelial CD31+ cells in the tumor microenvironment by significantly reducing host angiostatic and proinflammatory cytokines that restrain tumor development and increasing those for tumor growth. The gene discussed is PECAM1; the disease is pancreatic neoplasm.