Notably, the data presented in Figure 5, Figure 6 and Figure 7 suggest that the cancer cells at the early stage of tumor development orchestrated the angiogenic (IL-15, Il-18, M-CSF, VEGF, and FGFβ), proinflammatory (LIF, MIG, and MIP-2), and fibrogenic (PDGF-BB) cytokines to establish neovasculature to form blood vessels for tumor growth but decrease their effectiveness when the tumor starts to grow at day 35. The gene discussed is IL18; the disease is cancer.