APOL1 and infection: From intracellular functions linked to membrane dynamics (membrane traffic, fission and fusion), which control several infection-linked processes such as vesicular trafficking, apoptosis, and mitophagy as well as membrane disruption of intracellular bacteria [124], the APOL family of African primates evolved to include a novel function by a secreted member, APOL1, to kill the deadly bloodstream parasite T. brucei, responsible for the devastating sleeping sickness disease in humans and nagana in cattle [7].