These models revealed that the upregulation of the isoform δ of phosphoinositide-3-Kinasi (PI3K) promotes HCC cell plasticity, leading to the coexpression of epithelial and mesenchymal markers alongside pluripotency genes, such as sex-determining region Y-box 2 (SOX2), octamer transcription factor 4 (OCT4), and Nanog homeobox (NANOG) [29]. The gene discussed is NANOG; the disease is hepatocellular carcinoma.