In another patient-derived HCC organoids model, it has been found that peroxisome proliferator-activated receptor gamma coactivator 1-alpha gene (PPARGC1A) overexpression induced by lentivirus reduced the growth of organoids by inhibiting Wnt/β-catenin signaling and BAMBI production [40]. The gene discussed is PPARGC1A; the disease is hepatocellular carcinoma.