KLF4 and asthma: However, one inherent limitation of the model is that it leaves uncertain whether or not the identified hsa_circ_0008726-mediated induction of KLF4 via downregulation of endogenous hsa-miR-206-3p and the hsa_circ_0008726/hsa-miR-206-3p/KLF4 regulatory axis-mediated induction of M2 macrophage-associated markers and chemokines mechanism reflects similar lung immune responses that may participate in the early steps of asthma pathogenesis in occupational MDI-OA.