MFN2 and cyst: Mitofusin 2 (MFN2, an outer mitochondrial membrane GTPase facilitating mitochondria-ER proximity) expression was increased in PKD2 knockdown cell culture models and cyst-lining epithelial cells from human ADPKD kidneys, which enhances calcium transfer efficiency into mitochondria and promotes mitochondrial respiration (Figure 3B) [89].