PKD2 and Pancreatic cysts: Homozygous mutants of mouse Pkd2 die at embryonic day 13.5, exhibiting defects in the atrioventricular septum, renal cysts, and pancreatic cysts, while heterozygotes show milder pancreatic cysts, suggesting a dosage-dependent regulation of tissue function in mouse kidneys by PKD2 [69].