MKI67 and neoplasm: To assess the effects of NPS-1034 on the pathological changes and proliferation rate in the Renca-luc tumor, H&E staining and prognostic marker Ki-67 staining were used to explore the tumor histologic sections, as shown in Figure 5D. The tumor burden was estimated by determining the number of Ki-67-positive cells and the mean intensity of all Ki-67 staining (Figure 5E,F).