Similar observations regarding intracellular TLRs come from the study of Eskuri et al. In this study, samples from 564 patients with gastric adenocarcinoma were reanalyzed, and it was shown that patients with high nuclear TLR-3 expression had significantly worse 5-year survival compared to patients with low expression of this receptor (crude hazard ratio 1.31, 95% CI 1.07–1.60). Here, TLR3 is linked to gastric adenocarcinoma.