Analyses comparing the levels of soluble TLRs between the sexes of recruited patients revealed statistically significant associations for TLR-2 and TLR-4, as well as TLR-3 and TLR-9, between women with GC and healthy volunteers; women with GC and healthy men; and between men with GC and healthy men and men with GC and healthy women (Figure 7). Here, TLR4 is linked to gastric cancer.