GNRH1 and keratoconus: When GnRH saliva concentrations were analyzed based on age, the results showed that KC subjects of ages greater than or equal to 46 y/o had significantly lower GnRH saliva concentration (61.2 pg/mL, IQR 28.2–138.5 ng/mL) when compared to age-matched control patients (133.6 pg/mL, IQR 70.7–244.9 pg/mL, p = 0.0040, Figure 2C) suggesting that older KC subjects may have a larger differential in baseline GnRH levels compared to subjects aged 15–45 y/o.