PLK1 overexpression was noted in 60.3% (693/1149) of CRC cases and was significantly associated with larger tumor size (T3/T4 tumors; p = 0.0086), lymph node metastasis (<0.0001), Stage III tumors (p = 0.0008), deficient mismatch repair (dMMR) status (p = 0.0416). The gene discussed is PLK1; the disease is neoplasm.