We have recently shown that mice with DSS-colitis given JQ1 exhibit attenuation of the ongoing mucosal inflammation, which was paralleled by a reduction in the percentages of both CD3+T cells and CD11B+ CD11c+ cells and a significant reduction in RNA transcripts for TNF-α, IL-6, IL-17A, and IFN-γ, without affecting IL-10 RNA expression [16]. This evidence concerns the gene TNF and colitis.