PIEZO1 and airway hyperresponsiveness: Taken together, the present study provides evidence that ASMC hypertrophy can be directly linked to the enhanced contractile function of ASMCs and, thus, to the airway hyperresponsiveness and the essential role of Piezo1 in mediating this link, which may help not only better understand the pathogenic mechanism but also explore a specific therapeutic target for preventing/treating airway diseases associated with the ASMC hypertrophy such as severe asthma.