PIEZO1 and asthma: More recent studies in various cell types have shown that the mechanosensitive ion channel Piezo1 is highly regulated to drive Ca2+ signaling by cell volume-dependent membrane tension, suggesting that Piezo1 may be essential in relating the hypertrophy and hyper-contractility of ASMCs, and, thus, a potential target for treating hypertrophy-related AHR in severe asthma [19,20,21,22].