Inspired by these findings, we, thus, hypothesized that in ASMCs, the increase in single-cell volume could result in enhanced cell contractile function through regulation of Piezo1 and YAP crosstalk signaling, which might provide a direct mechanistic link between hypertrophy and hyper-contractility of ASMCs that might ultimately lead to AHR in severe asthma. This evidence concerns the gene PIEZO1 and asthma.