TADs harboring interacting promoters and enhancers in PCa cells correlated with local enrichment of CTCF, cohesin proteins, and AR/FOXA1 complexes to regulate gene transcription, while TAD rearrangements in castration-resistant prostate cancers (CRPC) affected the frequency of CRE-PCI interactions, resulting in altered transcriptional programming [84]. The gene discussed is CTCF; the disease is posterior cortical atrophy.