In this study, we describe the effects of three novel NRAS mutations—c.142G>T (G48C), c.127C>A (Q43K), and c.109G>A (E37K)—on cellular phenotypes, identified in a prospective, targeted, next-generation sequencing study of tumor samples from Filipino young-onset, colorectal cancer (YO-CRC) patients [20]. This evidence concerns the gene NRAS and neoplasm.