IRAK1 and colorectal carcinoma: Moreover, in 2021, a study on CRC by Feng et al. demonstrated that, following stimulation with IL-1β, the pharmacological inhibition of IRAK1 decreased cell migration in vitro and resulted in a significant increase in the epithelial marker E-cadherin levels and decrease in mesenchymal marker N-cadherin, vimentin, and Snail levels.