A study conducted on the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) highlighted the involvement of IRAK1 in the survival of ABC DLBCL cell lines via NF-κB signaling, the JAK kinase activation of STAT3, and the secretion of IL-6, IL-10, and IFN-β, all of which contribute to cell survival. Here, IRAK1 is linked to diffuse large B-cell lymphoma.