In a small clinical cohort, 66 IBD biopsy samples were analyzed, consisting of 38 UC and 28 Crohn’s disease (CD) tissue samples, along with 30 healthy colorectal mucosa samples, and PPARγ expression was decreased in samples of active UC, while PPARγ was significantly related to the activity of UC but not the severity of disease or location, and not in CD. The gene discussed is PPARG; the disease is irritable bowel syndrome.