FRMD3 and chronic kidney disease: Taking the data from our bulk RNA-seq together with these data from human single-nuclear RNA-seq datasets, it is possible that the observed inverse relationship between FRMD3 expression and CKD severity reflects both a loss of FRMD3 expression in the kidney together with a disease-driven loss of cells that that express FRMD3, e.g., proximal tubular epithelia and podocytes.