While previous studies have strongly linked single nucleotide polymorphisms associated with FRMD3 to the risk of development of DKD, relatively little is known about its function within the cell.11, –13 FERM domain-containing protein family members have been identified as key regulators of podocyte health.44,45 Published single cell transcriptomics datasets show FRMD3 to be widely expressed in the kidney, with expression detectable in proximal and distal convoluted tubule epithelial cells, podocytes, and glomerular endothelial cells, FRMD3 expression is reduced in DKD and CKD (Figure 3, C–F). This evidence concerns the gene FRMD3 and chronic kidney disease.