JMJD1C and acute myeloid leukemia: However, most of these cells have been demonstrated to be sensitive to JMJD1C depletion by shRNAs (Chen et al., 2015; Sroczynska et al., 2014), suggesting that the non-enzymatic function of JMJD1C must be responsible for the shared requirement of these AML cells for JMJD1C.