The requirement for JMJD1C has been demonstrated by shRNA knockdown and CRISPR/Cas9-mediated knockout analyses in various AML cell lines, including MLL-AF9, MLL-AF4, PML-RARα, and AML1-ETO, that harbor different translocations (Chen et al., 2015; Izaguirre-Carbonell et al., 2019; Sroczynska et al., 2014). Here, AFF1 is linked to acute myeloid leukemia.