Since LLPS of transcription regulators has been shown to facilitate the assembly and function of SEs (Hu et al., 2023; Li et al., 2023; Sabari et al., 2018; Wang et al., 2019), we next wanted to examine whether the LLPS ability of JMJD1C regulates the function of SEs and thus controls the RUNX1-regulated gene expression program in AML. This evidence concerns the gene RUNX1 and acute myeloid leukemia.