Growth curves demonstrated that RUNX1, like JMJD1C (Chen et al., 2015; Sroczynska et al., 2014), is required for all the cell lines that were examined (Figs. 1F–H and S2A–C), consistent with previous findings that RUNX1 is required for AML cells with MLL fusions and AML1-ETO (Ben-Ami et al., 2013; Goyama et al., 2013; Iida et al., 2022; Mill et al., 2019; Morita et al., 2017; Wilkinson et al., 2013). Here, RUNX1 is linked to acute myeloid leukemia.