JMJD1C and acute myeloid leukemia: Consistent with our screening results, and despite differences in their sensitivities toward JmjC and zinc finger domains-targeting sgRNAs, all cell lines tested were sensitive to sgRNAs targeting the JMJD1C N-terminal domain (Figs. 3G–I and S5D–H), further indicating the functional role of the JMJD1C N-terminal region in maintaining AML cell survival.