JMJD1C, the largest member of the Jumonji domain-containing lysine demethylase 3 (KDM3) family, is aberrantly expressed in various AML cells and is required for the survival of multiple types of leukemia (Chen et al., 2015; Sroczynska et al., 2014). The gene discussed is JMJD1C; the disease is acute myeloid leukemia.