Interestingly, in Kasumi-1 cells, GO analysis showed the enrichment of cell differentiation, proliferation, adhesion, and metabolic processes such as one-carbon metabolism and insulin-stimulated cellular response (Fig. S9C), whose alterations have been shown to contribute to AML growth and maintenance (Pikman et al., 2016; Pulikkottil et al., 2022). This evidence concerns the gene INS and acute myeloid leukemia.