Interestingly, several studies have reported a role for RUNX1 in supporting survival of many types of leukemia (Ben-Ami et al., 2013; Goyama et al., 2013; Iida et al., 2022; Mill et al., 2019; Morita et al., 2017; Wilkinson et al., 2013); and this function is not limited to the t(8;21) subtype, suggesting a potentially general RUNX1 requirement for leukemia survival, similar to that for JMJD1C. The gene discussed is JMJD1C; the disease is leukemia.