RUNX1 and acute myeloid leukemia: In AML with the t(8;21) translocation, the Runt DNA-binding domain of RUNX1 is fused to the ETO protein, producing a fusion protein, RUNX1-ETO, that was originally proposed to repress RUNX1 target gene expression to block differentiation (Amann et al., 2001; Liu et al., 2006, 2007).