Our analysis of JMJD1C and RUNX1 ChIP signals at loop anchors revealed that both JMJD1C and RUNX1 are significantly enriched at H3K27ac-enriched loop anchors but not at CTCF-enriched loop anchors (Figs. 7A and S10A), implying that they may regulate enhancer-involved three-dimensional chromatin structures in leukemia cells. The gene discussed is CTCF; the disease is leukemia.