For example, the H3K79 methyl transferase DOT1L and Menin, which interacts with MLL in conjunction with the H3K36 me2/3 reader LEDGF, have been shown to be especially important for MLL-AF9 leukemia (Bernt et al., 2011; Daigle et al., 2011; Lin et al., 2023). Here, DOT1L is linked to leukemia.