JMJD1C and acute myeloid leukemia: Since the JmjC domain is non-essential for the survival of all AML types that are dependent on full-length JMJD1C (shRNA knockdown experiments), we next performed CRISPR-Cas9 domain screening (Shi et al., 2015) to identify functionally important domains within JMJD1C that are commonly required for AML survival.