The major predictors listed were maternal characteristics, advanced maternal age, parity, pre-pregnancy weight, BMI, maternal characteristics and cervical length, maternal characteristics with biomarkers pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PLGF), UtA-PI, placental volume (PV), and pregnancy-related complication (previous history of hypertension, maternal characteristics with biomarkers and cervical length) (Figure 3). The gene discussed is PAPPA; the disease is hypertensive disorder.