PCK2 and cancer: Serine metabolism, often altered in cancer, facilitates de novo synthesis of biomacromolecules and GSH/NADPH, driving cancer cell proliferation and drug resistance.[13, 37] Our results indicate that IGF2BP3lac drives PCK2‐mediated substrate conversion (3‐PG) catalyzed by PHGDH into serine, supporting antioxidation reactions and biomass synthesis.