Increased FOXC1 expression due to gene duplication has been shown to result in anterior segment defects, including iris hypoplasia with glaucoma [50, 52], microcornea [51], and Peters anomaly [53], similar to the ocular features described here in the individual with a de novo RARB c.157+1895G>A variant. The gene discussed is RARB; the disease is Microcornea.