While this may suggest that there would be delayed treatment of patients with non-COL1A1/1A2 variants due to a significant difference in some of the more unique visual signs commonly attributed to OI, there was no significant difference in if patients had ever received a DEXA scan, the age of the patient during their first DEXA scan, or the Z-score from their DEXA scans suggesting no substantial delay in care is evident. The gene discussed is COL1A1; the disease is osteogenesis imperfecta.