Genes involved in the “RAS signaling”, “PI3K/AKT signaling”, mTOR signaling”, “MYC activation”, and “UPR signaling” pathways were also upregulated in venetoclax-resistant cells, further supporting the upregulation of alternative signaling pathways to drive venetoclax resistance in CLL (Figure 5B,C). Here, MYC is linked to B-cell chronic lymphocytic leukemia.