HMOX1 and B-cell chronic lymphocytic leukemia: SpiD3, but not FeCl2, decreased KEAP1 and increased HMOX1 protein levels in WT- and IR-HG3 cells (Figure 3E,F), indicating that SpiD3 can also induce oxidative stress, which may result in lipid peroxidation and the subsequent induction of ferroptosis in CLL.