Notably, “BCR signaling” and “PI3K signaling” pathways were decreased in IR-HG3 cells, but pathways critical for CLL proliferation and survival, such as “signaling by Rho GTPases”, “MAPK signaling”, “WNT/β-catenin signaling”, and “NOTCH signaling”, were increased in the ibrutinib-resistant cells (Figure 2C). This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.