Correspondingly, pathway enrichment analysis showed that “TNF signaling”, “TLR signaling”, “T-cell activation”, “NF-κB signaling”, “RANK-L/RANK signaling”, and “MHC class I and class II antigen processing and presentation” were upregulated in VR-OSUCLL cells (Figure 5C), highlighting potential vulnerabilities in venetoclax-resistant CLL cells. Here, TNF is linked to B-cell chronic lymphocytic leukemia.