Genes associated with the “ferroptosis”, “NRF2 signaling”, and “cellular response to oxidative stress” pathways (HMOX1, GCLM, and NQO1) were also upregulated in SpiD3-treated WT- and VR-OSUCLL cells, indicating that SpiD3 may induce ROS signaling, impairing the survival of CLL cells. Here, GCLM is linked to B-cell chronic lymphocytic leukemia.