In a rat model of bleomycin-induced pulmonary fibrosis, the Jagged 1/Notch1 signaling pathway has been observed to induce alpha-smooth muscle actin (α-SMA) expression via NF-κB activation, promoting endothelial mesenchymal transition (EndMT) and accelerating fibrosis (Yin et al., 2018). This evidence concerns the gene JAG1 and pulmonary fibrosis.